Phenolic profile and antimicrobial activity of dietary supplements based on Cochlospermum angolensis Welw
Artigo de Conferência
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resumo
Cochlospermum angolensis Welw. (borututu) is a widespread tree in Angola
that belongs to the Cochlospermaceae family. Its bark infusion is used in the traditional
medicine of Angola for the treatment of jaundice, hepatic diseases and for the
prophylaxis of malaria [1]. In the present work, three formulations based on this plant
(infusion, pills, and syrup) were characterized by HPLC-DAD-ESI/MS regarding
phenolic composition, and evaluated by their in vitro antimicrobial activity against
isolates of multiresistant bacteria (Escherichia coli, Escherichia coli spectrum
extended producer of β-lactamases (ESBL), Proteus mirabilis, methicillin-resistant
Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa).
The infusion and pills revealed the highest variety of phenolic compounds, with
eleven compounds identified. Protocatechuic acid was only present in infusions, being
the most abundant compound, while (epi)gallocatechin-O-gallate and
eucaglobulin/globulusin were the main molecules identified in pills and syrup,
respectively. Methyl ellagic acids, eucaglobulin/globulusin B (Fig. 1) and
(epi)gallocatechin-O-gallate were found in all the formulations. The infusion revealed
antimicrobial activity against all the studied bacteria with the exception of P. mirabilis
whereas the pills revealed activity in E. coli ESBL and MRSA. No significant
antimicrobial activity was detected in the syrup, in agreement with its low
concentrations of phenolic compounds. None of the tested formulations inhibited P.
mirabilis. Considering the obtained results, C. angolensis infusion can be considered a
good source of phenolic compounds as well as a good antimicrobial agent.
