New cytotoxic neolignans from the cobalt crust fungus
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Terana coerulea (Phanerochaetaceae family) is known as the cobalt crust fungus and it
is used for its antibiotic properties at the Irati’s Forest (Navarra, Spain). Previous
mycochemical investigations reported the isolation of corticins A-C,[1] p-terphenyl
neolignans related to the antitumoural telephoric acid.[2] In this job, from powdered
dry fungi, six extracts of increasing polarity were obtained and tested for cytotoxicity
against four human tumour cell lines and one non-tumour primary cell culture with the
sulforhodamine B assay. From the most cytotoxic one, the EtOAc extract, we isolated
and identified three p-terphenyl neolignans. One of them was previously described as
corticin A by Briggs et al.,[1] whose earlier structure has been revised in this work using
one- and two-dimensional NMR, HRMS, positive and negative MS/MS and its peracetyl
derivative in comparison with 4’’-deoxy and 4,5-dimethoxy candidusines A.[3] The
other two neolignans are new natural products, named corticins D and E. These
neolignans were less cytotoxic than the EtOAc extract itself, maybe due to an aerial
oxidation and degradation produced when these neolignans, with catechol moieties,
are definitively purified.
