Nepeta nuda tincture Vs. Listerine – who wins the battle against oral pathogens?
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resumo
Antimicrobial activity of Nepeta nuda L. (Lamiaceae) tincture and Listerine against a selected
group of oral pathogenic microorganisms (4 bacterial species and 9 fungal strains) was explored.
The activity of N. nuda tincture and Listerine to inhibit the formation of biofilm has been compared
as well as their potential to demolish biofilm that is already established. Furthermore, based on in
vitro experiments, the amount of N. nuda tincture and swishing time necessary for reaching better
or equivalent antimicrobial effect as Listerine were predicted. Chemical constituents in N. nuda
tincture regarding phenolic compounds were determined by LC-DAD/ESI-MSn. Both Listerine and
N. nuda tincture possessed good antimicrobial potential, and acted on biofilms on two different
developmental stages. When dealing with bacteria that have biofilm forming ability, N. nuda tincture
would be highly recommended since it showed much better potential to inhibit formation
of biofilms. For application via swishing, both mouthwashes should be used for 30 s when dealing
with selected microorganisms in general and for 60 s (N. nuda tincture, 100 mg mL-1) when dealing
with bacterial biofilms. Recommended volume of liquid for swishing is 20 mL. Chemical profiling
showed rosmarinic acid and verminoside as the most dominant phenolic compounds present
in the N. nuda tincture. So, who wins this battle? The authors could conclude that both mouthwashes
stand shoulder to shoulder when it comes to exhibiting antimicrobial potential, and since
Listerine has been in wide use for long time period, and it would be an attractive challenge to put
some competition on the market.
