Virtual screening of a library of natural compounds against COX-2 protein
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resumo
The use of nonsteroidal anti-inflammatory drugs
(NSAIDs) in treating inflammatory diseases has been
widespread, especially in treating rheumatoid arthritis.
NSAIDs act mainly by promoting the inhibition of
cyclooxygenase enzymes (COX-1 and COX-2), inducing
significant anti-inflammatory, analgesic, and antipyretic
activity. However, recent data show that prolonged use of
NSAIDs can lead to cardiovascular side effects. Thus, the
present work aims to identify COX-2 inhibitors
alternatives from natural sources, specifically mushrooms,
as an alternative to conventional inhibitors
