Diversity patterns of P450 and ABC transporter genes in 17 honey bee subspecies
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resumo
Honey bees (Apis mellifera) inhabit a vast geographical range, spanning
diverse natural and agricultural ecosystems. They are exposed to different
levels and types of natural (such as plant allelochemicals) and synthetic
(such as pesticides) xenobiotics within this range. Several genes have been
implicated in the resistance of insects to pesticides, including the P450
monooxygenases superfamily and ATP-binding cassette sub-family F
member 1that contain 46 and 41 genes, respectively. Here, the sequences
of P450 monooxygenases and ABC transporters from >1500 individuals
representing 17 subspecies of the four honey bee main lineages will be
analyzed. The functional annotation and effects of each variant will then
be predicted using SnpEff and the allele frequency and FST (fixation index)
of each SNP per population and evolutionary lineages will be calculated. It
is expected to have highly differentiated SNPs among the different
subspecies/lineages.
